Inspiring and accelerating action to end the opioid crisis.
FORE is a national grantmaking foundation committed to convening and supporting partners advancing patient-centered, innovative, evidence-based solutions.
The Pine Ridge Reservation covers a vast area of South Dakota with limited cellphone and internet service, making it challenging for organizations that support families affected by opioid use to share expertise and resources. A grant from FORE enabled 16 organizations across the reservation to come together and share the innovative methods they are developing to promote resilience and prevent substance use disorder and overdose in youth.
The multi-sector coalition includes organizations that specialize in substance use prevention and treatment, healthcare, education, housing, and public safety. Each has a unique vantage point and means to engage Indigenous youth, who experience significantly higher rates of adverse childhood experiences that put them at heightened risk of suicide, depression, and substance use.
In a new video released in honor of Indigenous Peoples’ Day, two organizations that are part of the coalition — Project Venture and the Oglala Lakota Children’s Justice Center — describe how coalition members are working to reduce the risk of suicide and substance use by creating opportunities for young people and their families to engage in Lakota ceremony and culture.
“The families who come to us are hurting. We help them to let that emotion out by taking those who want to through ceremony that soothes the spirit,” says Arlana Bettelyoun, Executive Director of the Oglala Lakota Children’s Justice Center, a child advocacy organization. “It is profound to see how they work through things and develop an appreciation for who they are,” she says.

This week we brought together our over 120 #FOREgrantees - clinicians, researchers, first responders, people with lived experience, advocates, family members, community leaders, and more - to learn, collaborate, problem solve, and pave the way forward towards addressing the nation’s #opioid and #overdose crisis. From taking a deeper dive into the current data to practicing new communication techniques, our FORE family has left more energized than ever, ready to continue to roll up our sleeves, do the hard work, and save lives.

A HUGE congratulations to #FOREgrantee Dr. Nabarun Dasgupta on today being named a 2025 MacArthur `Genius` Fellow! He has been an incredible partner in working with FORE to tackle the nation`s #opioid and #overdose crisis. We are so, so proud to have been able to support him as he began his innovative nationwide #drugchecking program in 2022. Congratulations, Nab, and we can`t wait to see what you do next!

Although American Indian and Alaska Native communities have been disproportionately impacted by the #opioid and #overdose crisis in the U.S., #prevention strategies often fail to account for culturally-specific practices, tribal beliefs, and impact of historical and present-day trauma. Indigenous adolescents are at particularly high risk. They are not only more likely to die from drug overdoses than all other racial and ethnic groups, but also experience significantly higher rates of adverse childhood experiences, including trauma, that put them at heightened risk of suicide, depression, and substance use.
Communities need evidence-based, culturally-grounded prevention programs to support healthy generations of Indigenous youth. A new video highlights how Project Venture, a FORE grantee, fosters resilience among Indigenous youth living on the Pine Ridge Reservation in South Dakota, one of the largest tribal reservations in the U.S. and also the poorest. The experiential education program engages youth in outdoor adventures, service activities, and leadership training over the course of a school year — a model that’s been shown to reduce substance misuse and promote self-awareness.
The program fosters a connection to Indigenous culture and the natural world as a means building self-esteem and problem-solving skills. It follows a strengths-based approach — creating opportunities for young people to test and expand their leadership skills. FORE funding has enabled nearly 600 students to participate in the program over the last three years; an evaluation found increases self-reported measures of empathy and self-awareness. “It’s thanks to FORE that we’re able to accomplish that,” says Alfred Kahn, Project Venture’s executive director.

This week, FORE presented at the 2025 National Prevention Network Conference in Washington, D.C. alongside our #FOREgrantees @uofwa Social Development Research Group, @sesameworkshop, and @moco_partnership. Together, we shared achievements and findings from their FORE-supported projects that deliver evidence-based, whole-family prevention interventions that equip parents, caregivers, and communities that have been disproportionately impacted by the #opioid and #overdose crisis, and improve lifelong health outcomes for families with upstream approaches to substance use disorder #prevention.
#NPNConference

Today, FORE staff travelled to Philadelphia to celebrate the investiture of #FOREgrantee Lara Carson Weinstein, MD, MPH, DrPH as the Stephen and Sandra Sheller Distinguished Professor of Supportive Healthcare at @jeffersonhealth. Congratulations, Dr. Weinstein!


RFP: Community-Driven Responses to Opioid Use Disorder and Overdose Mortality 2025
The Community-Driven Responses to Opioid Use Disorder and Overdose Mortality 2025 RFP closed on July 2, 2025.
Update on 8/15: Due to the high volume of Concept Notes received, applicants can expect to hear about the status of their application in the coming weeks. We thank you for your patience and understanding!
More details can be found on our Grants & Funding page.
Recognizing An Urgent Need
The opioid crisis is impacting families and communities across the country. An estimated 133 Americans die every day (48,422 in the past 12 months) from an opioid overdose1, and an estimated 4.8 million experience an opioid use disorder2, affecting individuals, families, and communities across the nation.
Now more than ever, it is critical for us to think creatively, test new approaches, remove silos, and enhance and expand activities proven to prevent and reduce opioid use disorder.
1Provisional reported as of April 2025, U.S. Centers for Disease Control and Prevention, 2025
2Substance Abuse and Mental Health Services Administration, 2025
We are committed to convening and supporting partners advancing patient-centered, innovative, evidence-based solutions addressing the opioid crisis. With patients at the center, we are focused on promoting excellence and supporting programs and grants in four key areas: Professional education, payer & provider strategies, policy initiatives, and public awareness.
See Our Grantmaking Approach